Sr Scientist, Early Target Discovery - Technology DevelopmentApply Now Job ID 1603140 Date posted12/14/2016 LocationSan Diego, California, United States;
- Leads a group of scientists in development of new technologies to expand the capabilities of the bacTRAP group
- Assesses and accesses external technology to enable the most effective and technically current operation of the group
- Leads the design of new BAC, plasmid and viral constructs for the genetic profiling and manipulation of physiologically important cell types in vivo
- Applies expertise in mouse genetics and vector design to plan and undertake cell specific transgenic approaches and in vivo gene delivery experiments
- Rapidly and efficiently transfers newly developed technologies to the core bacTRAP group for routine use
- Works closely with the core bacTRAP group to optimize the use of newly developed technologies for specific projects
- Establishes the routine use of stereotactic injections using a variety of chemical compounds, viral vectors, and anatomical tracers as needed for genetic and pathway assessment, molecular profiling, and physiological studies in vivo
- Works and communicates effectively with colleagues of differing backgrounds and experience levels
- Represents the Department at project team meetings and scientific meetings
- Keeps up to date with appropriate literature and scientific developments and use knowledge to propose new programs or support current programs
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
- Ph.D. in relevant field of biology with 4+ relevant years of experience OR
- MS/MA with 14+ relevant years OR
- BS/BA with 16+ relevant years
- Experience in manipulating the expression of biological targets in vivo and in vivo pharmacology
- Breadth of knowledge in existing and developing molecular technologies, including bacTRAP, CRISPR/Cas9, Single cell seq, RNAseq, IPSCs, GCaMP, and human genetics
- Strong background in using and/or developing new technologies for in vitro and in vivo transcriptional regulation and assessment of gene function
- Highly experienced in in vivo gene delivery systems
- Well versed in technologies used for activating or inhibiting specific cell types using optogenetics and/or RASSLs/DREADDs
- Management of multiple tasks of varied complexity simultaneously
- Skilled in statistical analysis, graphing programs and PowerPoint presentations
- Excellent written and verbal communication skills
- Effective presentation skills – create and deliver presentations with appropriate messaging and focused recommendations
- Carrying, handling and reaching for objects up to 25 lbs.
- Able to work in a lab environment
- May travel to the US and Japan offices and other meeting locations internationally.
- Approximately 10% travel is required.
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