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Sr Director / Director, CNS Research

Job ID 1602831 Date posted12/15/2016 LocationSan Diego, California, United States;
Please note that the requirements specified in this posting are the basic qualifications required for the Director position; however, job title will be dependent on the candidate's level of experience in those requirements.
More than 30,000 Takeda employees working in more than 70 countries are committed to improving quality of life for patients, who remain at the center of everything we do. As a global, research and development-driven pharmaceutical company, Takeda Pharmaceutical Company Limited conducts R&D both internally and with external partners to translate science into life-changing medicines. Takeda focuses on the core therapeutic areas of oncology, gastroenterology and central nervous system, plus vaccines. Novel products, especially in oncology and gastroenterology, as well as our presence in Emerging Markets, fuel our growth.
While Takeda is enjoying tremendous growth as an emerging global leader in the pharmaceutical industry, we remain ever mindful of our commitment to serve people worldwide by striving toward better health through leading innovation in medicine. In short, we are a passionate team doing important work that impacts patients’ lives. If you are driven to create better health and a brighter future, join us!

The Director of CNS Research acts as the strategic leader for research activities for the TCAL CNS DDU  team that translate human patient data sets and internal bacTRAP data into drug discovery projects that generate  clinical assets that will be assessed in small patient populations for their potential to become transformational medicines for patients suffering from CNS disorders.
The specific focus of the TCAL CNS DDU group will be to  build and prosecute, through both internal and external partnerships, a portfolio of therapeutic approaches that modify neuronal circuit activity to treat psychiatric  indications such as schizophrenia.


  • Guided by the DDU and TAU strategy, sets the strategy for the TCAL CNS DDU group
  • Leads the selection of new drug targets and executes efficient preclinical and clinical validation, incorporating target engagement and/or functional biomarkers of drug action
  • Expands portfolio to incorporate large molecule therapeutics and collaborates with the Takeda functions and external partners to enable their progression to clinical PoM.
  • Develops an innovation portfolio with Takeda partners, CROs and academic collaborators that can test and deliver the next generation of CNS drug discovery concepts
  • Seeks, evaluates and proposes preclinical/clinical in-licensing candidates.
  • Identifies, engages, and ensures the success of research partnerships across Takeda’s global network and the external scientific community.
  • Keeps up-to-date with the latest scientific advancements (e.g. competitive situation, new technologies and partnerships) and is well informed about current regulatory (FDA etc.) requirements and trends.
  • Sets departmental scientific and business goals and manages the financial budget  and other administrative functions
  • Has significant accountability for the performance and results of functional groups or strategic business, scientific or support function
  • Leads, coaches, and provides direct scientific leadership to group members
  • Works with the leadership team, TREC and TAU to allocate appropriate resources to ensure timely achievement of pipeline and technology goals
  • Develops talent within the department, providing performance feedback and training opportunities.
  • Implements initiatives and best practices to ensure an open and free scientific culture that is rich in diversity.
  • Collaborates with senior management to manage company operations, set company-wide policies and ensure compliance



  • PhD in Life Sciences or equivalent with at least 10 years of relevant experience
  • Well informed in all areas of drug discovery from target identification through preclinical research, including biomarker, and PK/PD/Tox assays.
  • Track record of accomplishment in research as evidenced by quality and quantity of publications and/or inventions and/or products and clinical candidates.
  • Track record of leading complex cross-functional collaborations
  • Demonstrated ability to organize the activities of a large team of scientists working in highly diverse scientific areas, including managing relationships with academic collaborators and CROs.
  • Excellent written and verbal communication skills, including preparation and organization of data for efficient presentation to any internal or external senior audience or partner.

  • Manual dexterity required to operate office equipment (i.e. computers, phones, etc.).   
  • Ability to sit for long periods of time
  • Carrying, handling and reaching for 25 lb. objects.
  • Willingness to travel to various meetings or client sites, including overnight trips.
  • Some international travel will be required, likely several times yearly.
  • Requires approximately 15% or more travel.

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