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Sr. Scientist siRNA Technologies - DMPK

San Diego, California


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Takeda California generates highly disease-specific and patient-tailored transformative new medicines aligned with Takeda’s global market strategies through research in Gastrointestinal (GI), Neuroscience and Immunology. Takeda California’s team of experienced scientists and clinicians deliver on the needs of patients by blending its internal capabilities, global Takeda resources, and expertise and technology from best-in-class external partners. Takeda California has opened a new 165,000 square-foot building which is an external innovation and collaboration hub for San Diego.

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Sr. Scientist siRNA Technologies - DMPK

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Job ID R0029379 Date posted 03/17/2021 Location San Diego, California

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?  Join us as a Sr. Scientist siRNA Technologies at our newly dedicated San Diego, CA Site.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company.  To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do.   We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.  As a Scientist working in new modalities on the DMPK team, you will be empowered to serve on project teams for discovery to development programs.

As a member of Drug Metabolism and Pharmacokinetic (DMPK) group at Takeda California (TCAL), you will participate in drug discovery and early development through the conduct of in vitro and in vivo drug metabolism studies designed to understand absorption, distribution, biotransformation pathways and routes of elimination of diverse therapeutic modalities such as peptides, peptidomemetics, peptide conjugates, Antibody-Drug Conjugates (ADC) with focus/emphasis on Oligonucleotides (siRNA and ASOs) as well as to guide synthetic efforts and to identify potentially active/reactive catabolites/fragments. Experience in performing quantitative analyses of these modalities is highly preferred.

Qualified candidates will have experience in the pharmaceutical or biotech industry with hands-on experience with selecting, operating, and maintaining mass spectrometric equipment for the purposes of qualitative and quantitative analyses of therapeutic modalities such as peptides, peptidomemetics, peptide conjugates, Antibody-Drug Conjugates (ADC) with focus/emphasis on Oligonucleotides (siRNA and ASOs).  The candidate should have (extensive) experience in the optimization of oligonucleotide extraction protocols and development of the first in-house method for high-resolution LC-MS/MS-based biotransformation and quantification of oligonucleotides/linkers/conjugates in complex biological matrices (liver, extrahepatic tissues, plasma, urine).  The candidate should have (extensive) experience interpreting mass spectral data to make structural assignments.  Hands-on experience with radioactivity is essential and experience with common chemical derivatization techniques to identify site of metabolism, use of isotopically labeled reagents to aid the understanding of enzyme reactions are highly desirable.  In addition, candidate should have fundamental understanding of various DMPK areas such as physicochemical properties, PK, drug metabolizing enzymes, as well as transporter kinetics.  A qualified individual will be expected to collaborate in a team environment with both internal members of the group as well as discovery/early development project teams. A successful candidate will require excellent interpersonal skills, particularly oral and written communication skills.


  • PhD degree in physical organic chemistry, computational chemistry or a related field with 2-5+ years of experience

  • MS with 8+ years of experience, or

  • BS with 10+ years of experience


  • 401(k) with company match and Annual Retirement Contribution Plan

  • Tuition reimbursement

  • Company match of charitable contributions

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs

This job posting excludes CO applicants

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San Diego, CA

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Job ID R0029379
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