Sr. Scientist siRNA Technologies - DMPK
San Diego, California
Takeda fosters a collaborative and stimulating work environment filled with opportunity and the chance to make a difference in people's lives. It is a workplace driven by integrity, one of Takeda’s long-held values that extends to both the patients we serve and our employees who develop and deliver medicines. Across our company, Takeda employees bring together diverse strengths that together create a stronger whole.
As one of the world’s leading biopharmaceutical companies, Takeda is committed to bringing Better Health and a Brighter future to people worldwide. We aspire to bring our leadership in translating science into life-changing medicines to the next level, in our core focus areas; oncology, gastroenterology, neuroscience, rare diseases, plasma-derived therapies, and vaccines.
Takeda California generates highly disease-specific and patient-tailored transformative new medicines aligned with Takeda’s global market strategies through research in Gastrointestinal (GI), Neuroscience and Immunology. Takeda California’s team of experienced scientists and clinicians deliver on the needs of patients by blending its internal capabilities, global Takeda resources, and expertise and technology from best-in-class external partners. Takeda California has opened a new 165,000 square-foot building which is an external innovation and collaboration hub for San Diego.
We are a passionate team doing important work that impacts patients’ lives. If you are driven to create better health and a brighter future, join us!
What makes a successful member of our team? Check out the traits we’re looking for and see if you have the right mix.
- Results Driven
- Team Player
Life at Takeda
Medicine for the world
We put the patient at the center of everything we do as we strive towards better health for people worldwide, through leading innovation in medicine.
Research & Development
By focusing R&D efforts on four therapeutic areas and other targeted investments, our aim is to thrive at the cutting edge of innovation that solves unmet medical needs, through internal R&D and in collaboration with cross-industry partners.
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Meet Jen, the Chief of Staff and Head of Gastroenterology (GI) Therapeutic Area Unit General Operations in Boston, Massachusetts.
Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
Since 1781, the values of Takeda-ism (Integrity, Fairness, Honesty, and Perseverance) have guided everything we do—from decision-making to interacting with patients.
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A strong, borderless team, we strive together towards our priorities and inspiring mission.
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Sr. Scientist siRNA Technologies - DMPKApply Now
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Sr. Scientist siRNA Technologies at our newly dedicated San Diego, CA Site.
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Here, you will be a vital contributor to our inspiring, bold mission. As a Scientist working in new modalities on the DMPK team, you will be empowered to serve on project teams for discovery to development programs.
As a member of Drug Metabolism and Pharmacokinetic (DMPK) group at Takeda California (TCAL), you will participate in drug discovery and early development through the conduct of in vitro and in vivo drug metabolism studies designed to understand absorption, distribution, biotransformation pathways and routes of elimination of diverse therapeutic modalities such as peptides, peptidomemetics, peptide conjugates, Antibody-Drug Conjugates (ADC) with focus/emphasis on Oligonucleotides (siRNA and ASOs) as well as to guide synthetic efforts and to identify potentially active/reactive catabolites/fragments. Experience in performing quantitative analyses of these modalities is highly preferred.
Qualified candidates will have experience in the pharmaceutical or biotech industry with hands-on experience with selecting, operating, and maintaining mass spectrometric equipment for the purposes of qualitative and quantitative analyses of therapeutic modalities such as peptides, peptidomemetics, peptide conjugates, Antibody-Drug Conjugates (ADC) with focus/emphasis on Oligonucleotides (siRNA and ASOs). The candidate should have (extensive) experience in the optimization of oligonucleotide extraction protocols and development of the first in-house method for high-resolution LC-MS/MS-based biotransformation and quantification of oligonucleotides/linkers/conjugates in complex biological matrices (liver, extrahepatic tissues, plasma, urine). The candidate should have (extensive) experience interpreting mass spectral data to make structural assignments. Hands-on experience with radioactivity is essential and experience with common chemical derivatization techniques to identify site of metabolism, use of isotopically labeled reagents to aid the understanding of enzyme reactions are highly desirable. In addition, candidate should have fundamental understanding of various DMPK areas such as physicochemical properties, PK, drug metabolizing enzymes, as well as transporter kinetics. A qualified individual will be expected to collaborate in a team environment with both internal members of the group as well as discovery/early development project teams. A successful candidate will require excellent interpersonal skills, particularly oral and written communication skills.
EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
PhD degree in physical organic chemistry, computational chemistry or a related field with 2-5+ years of experience
MS with 8+ years of experience, or
BS with 10+ years of experience
WHAT TAKEDA CAN OFFER YOU:
401(k) with company match and Annual Retirement Contribution Plan
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
This job posting excludes CO applicants
Empowering Our People to Shine
Learn more at takedajobs.com.
No Phone Calls or Recruiters Please.
LocationsSan Diego, CA
Time TypeFull time
Job ID R0029379