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Principal Scientist, Bioconjugation and Oligonucleotide Chemistry

San Diego, California

Overview

Takeda fosters a collaborative and stimulating work environment filled with opportunity and the chance to make a difference in people's lives. It is a workplace driven by integrity, one of Takeda’s long-held values that extends to both the patients we serve and our employees who develop and deliver medicines. Across our company, Takeda employees bring together diverse strengths that together create a stronger whole.

As one of the world’s leading biopharmaceutical companies, Takeda is committed to bringing Better Health and a Brighter future to people worldwide. We aspire to bring our leadership in translating science into life-changing medicines to the next level, in our core focus areas; oncology, gastroenterology, neuroscience, rare diseases, plasma-derived therapies, and vaccines.

Takeda California generates highly disease-specific and patient-tailored transformative new medicines aligned with Takeda’s global market strategies through research in Gastrointestinal (GI), Neuroscience and Immunology. Takeda California’s team of experienced scientists and clinicians deliver on the needs of patients by blending its internal capabilities, global Takeda resources, and expertise and technology from best-in-class external partners. Takeda California has opened a new 165,000 square-foot building which is an external innovation and collaboration hub for San Diego.

We are a passionate team doing important work that impacts patients’ lives. If you are driven to create better health and a brighter future, join us!

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What makes a successful member of our team? Check out the traits we’re looking for and see if you have the right mix.

  • Collaborative
  • Strategic
  • Results Driven
  • Team Player
  • Versatile
  • Entrepreneurial

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Opportunity

  • Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.

  • Since 1781, the values of Takeda-ism (Integrity, Fairness, Honesty, and Perseverance) have guided everything we do—from decision-making to interacting with patients.

  • Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.

  • Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

  • A strong, borderless team, we strive together towards our priorities and inspiring mission.

  • Recognized for our culture and way of working, we’re one of only 13 companies to receive Top Global Employer® status for 2020.

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Principal Scientist, Bioconjugation and Oligonucleotide Chemistry

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Job ID R0030945 Date posted 03/02/2021 Location San Diego, California

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Oligonucleotide Lead in our San Diego, CA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

OBJECTIVES/PURPOSE

  • Independently designs and implements extensive scientific research projects relating to the development of antisense oligonucleotide or siRNA therapeutics. Contributes to multiple projects, acting as senior scientific consultant, may be a project team leader or providing key technical knowledge to a project team.

ACCOUNTABILITIES                                                                                                                                                                               

  • Plays a leading role in the identification, development, validation and implementation of both current and next-generation delivery technologies to enable proprietary ASO and siRNA therapeutic development including purchase and installation of hardware and software supporting synthesis, purification, and characterization of oligonucleotides
  • Executes or directs bioconjugation of targeting ligands to oligonucleotides in the lab and/or through effective management of external CRO teams
  • Demonstrates working knowledge of techniques aimed at producing novel conjugates of oligonucleotides, peptides, small molecules, and proteins
  • Build and lead a small internal team of chemists and manage external CRO workstreams as needed.


DIMENSIONS AND ASPECTS

Technical/Functional (Line) Expertise

  • Proven track record of scientific contributions in the bioconjugation and oligonucleotide research/development as evidenced by quality and quantity of publications/presentations/inventions and/or products and clinical candidates
  • Demonstrates a deep understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides as applied to both antisense oligo and siRNA technology within a multi-disciplinary drug discovery environment.
  • Maintains a current appreciation of the scientific literature and understanding of the state of the art in ASO and siRNA chemistry, purification, and screening strategies
  • Demonstrates inter-disciplinary knowledge of drug discovery (in vitro/in vivo pharmacology, ADME, PK/PD, translational research & toxicology).
  • Demonstrates strong analytical; and bioanalytical skills to characterize oligonucleotides and their conjugates using a variety of techniques including but not limited to LC-UV-HRMS, SEC/SAX/IPRP, Gel based methods, fluorophore labeling.

Leadership

  • Recognized as a major contributor and/or leader of multi-disciplinary projects, with significant accountability for progress on projects important to achieving site goals.
  • Prepares and organizes data for presentation. Communicates strategy and results in written and oral reports to various levels of management.  Communicates research efforts to collaborators, corporate partners, or at scientific meetings.
  • Strategic direction of bioconjugation and oligonucleotide chemistry capability development at Takeda. Identifies, proposes and develops new solutions to discovery strategy.
  • Strong and effective manager of both junior and senior scientists, demonstrating exemplary behaviors and able to support and enhance career development of all line reports.
  • Scientific driver for research strategy that impacts group internally and outside area of function.
  • Highly motivated and flexible with ability to work in fast-paced environment. Ability to provide novel creative solutions to challenging problems.  Desire to learn and tackle new challenges and initiatives.

Decision-making and Autonomy

  • Scientific driver for research strategy that impacts group internally and outside area of function

Interaction

  • Provides expert input in evaluation of external/partnership opportunities, including participating in diligence exercises. Initiates and leads external interactions and collaborations.
  • Positive can-do attitude with excellent communication and collaboration skills and ability to work with cross-functional scientists. Ability to clearly and concisely conveys ideas and opinions.

Innovation

  • Leads effort to identify emerging trends in bioconjugation, targeted delivery of oligonucleotide therapeutics and maintains awareness of competitive landscape
  • Develops and contributes to company’s intellectual property domain by way of patents and publications.

EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:

  • Ph.D. in Organic Chemistry (or a related field) with thesis, publication(s), postdoctoral experience, and a minimum of 8 years relevant scientific and technical experience including industry experience, or
  • MS with 12+ years experience, or
  • BS with 14+ years experience

This job posting excludes CO applicants

WHAT TAKEDA CAN OFFER YOU: 
•    401(k) with company match and Annual Retirement Contribution Plan
•    Tuition reimbursement Company match of charitable contributions
•    Health & Wellness programs including onsite flu shots and health screenings
•    Generous time off for vacation and the option to purchase additional vacation days
•    Community Outreach Programs

Empowering Our People to Shine

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Locations

San Diego, CA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job ID R0030945
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