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Pilot Plant Engineer III

Lexington, Massachusetts


Takeda fosters a collaborative and stimulating work environment filled with opportunity and the chance to make a difference in people's lives. It is a workplace driven by integrity, one of Takeda’s long-held values that extends to both the patients we serve and our employees who develop and deliver medicines. Across our company, Takeda employees bring together diverse strengths that together create a stronger whole.

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  • Since 1781, the values of Takeda-ism (Integrity, Fairness, Honesty, and Perseverance) have guided everything we do—from decision-making to interacting with patients.

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Pilot Plant Engineer III

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Job ID R0023105 Date posted 10/16/2020 Location Lexington, Massachusetts

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Job Description


The individual will be a member within a group responsible for performing large scale cell culture and purification operations/development, including expansion and production bioreactor operation, capture, and purification of non-GMP batches to support development timelines. They will collaborate within the upstream and downstream pilot teams and with the process development team. This individual is responsible for independently executing basic/routine and complex experiments and unit operations. Additionally, this position participates in planning unit operations/experiments under supervision and drafting support documentation (SOPs, batch records, and/or reports). They will apply knowledge from various technical areas, industry practices and standards under close supervision and provide quality and productive output that is consistently timely, reliable and reproducible. The candidate must be customer focused, results oriented, science driven, and have high attention to detail.


  • Works with departmental and/or cross functional peers to execute on assignments, under limited supervision.
  • Documents data accurately in laboratory notebooks and batch records completely as per established company guidelines/SOPs. Writes documents such as reports, protocols and internal presentations that may require substantial edits. Assists senior personnel with publications, external abstracts and presentations, as needed.
  • Organizes and presents issues and results at departmental and project meetings.
  • Contributes significantly to project work which may include multiple projects within functional area.
  • Interprets data independently, and contributes to technical reports
  • Identifies complex technical issues, and implements solutions under supervision
  • Contributes to the design of new applications/experiments/unit operations in consultation with supervisor.
  • Supports technology transfer through writing and consolidating technical documents.
  • Coordinates within department as well as cross functionally with peers on projects


Education and Experience:


  • Associates degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science and 4+ years relevant industry experience
  • Bachelors degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science; 2+ years relevant industry experience
  • Masters degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science; 0+ years relevant industry experience
  • Previous experience working in lab setting or Masters degree plus appropriate laboratory training

Knowledge and Skills:

  • Analytical and Problem-Solving Skills -Able to troubleshoot critical issues or problems and resolve routine issues using appropriate information. Stands accountable and consistently follows through on work assignments and personal objectives to deliver high quality results despite obstacles.
  • Teamwork -- Ability to work within department groups/team.
  • Communication Skills - Expresses one’s self clearly and concisely within function; documents issues and/or concerns concisely with colleagues; timely and effectively communicates issues to supervisor
  • Organization – Exercises good time management skills. Effectively manages multiple priorities and outcomes of critical tasks.
  • Technical - Proficient in use of applicable lab equipment and operations


  • Ability to wear personal protective equipment such as safety glasses/goggles, gloves and safety shoes.
  • Ability to lift, pull or push equipment requiring up to 25-50 lbs of force.
  • Ability to stand for 6 hours in a suite.
  • Ability to climb ladders and work platforms.
  • Stooping or bending to check or trouble-shoot equipment operations.


  • The candidate may be asked to travel occasionally (domestically and internationally) for conferences, seminars, and project specific needs (approximately 5% travel).


Biologics – Pilot Plant:

  • Experience with either cell culture or purification is required as this role will support both upstream and downstream operations. Experience with cell culture and aseptic techniques; Experience with laboratory equipment that supports cell culture, such as bioreactors, metabolite analyzers, shake flasks, cell culture plates; Experience with using automation preferred; Good understanding of chromatographic and other protein separation principles; Familiarity with use of bioseparation equipment and standard analytical assays.
  • May be required to adjust work schedule to meet operational demands.
  • Work includes a combination of cell culture (seed train/expansion/production bioreactor), harvest operations (filtrations or centrifugation), buffer planning and ordering, scheduling, large-scale column packing, sample forecasting and submission, metabolite or sample measurement, assisting with assembly and disassembly of process equipment, authoring batch records/SOPs or proposing document revisions, and execution of these records in a non-GMP environment. The individual may contribute to the evaluation of novel, generic platform technologies that can be applied across multiple programs.


Lexington, MA

Worker Type


Worker Sub-Type


Time Type

Full time

Job ID R0023105

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