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Ph.D. Researcher (in vitro/ vivo), Oligonucleotide DDS/ 核酸医薬DDS博士研究員

Apply Now Email Me Job ID R0005471 Date posted 11/22/2018 Location: Fujisawa, Japan

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Job Description

[Introduction of Takeda]

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Oligonucleotide DDS researcher in our Shonan Health Innovation Park.

Takeda is a global pharmaceutical leader with more than 30,000 professionals working together. We have an unwavering dedication to put people first and we live our values of Takeda-ism: Integrity, Fairness, Honesty, and Perseverance. We are united by our more than 230-year legacy of research-based pharmaceuticals and our mission to strive toward Better Health and a Brighter Future for people worldwide through leading innovation in medicine.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. At Takeda, you will make an impact on people's lives – including your own.

タケダでは、常に患者さんを中心に考え、その生活を豊かにするためにイノベーションを推進しています。そして、従業員一人ひとりにそれぞれの能力と熱意に応じた成長の機会を提供することにも組んで取り組んでいます。私たちと一緒に、世界中の人々のいのちに貢献し、さらなる成長と活躍を目指しませんか。

タケダは2万7千人以上の従業員が、54以上の国や地域で働くグローバルな企業です。すべての従業員が世界中の人々の生活をより良いものにしたいという信念をもち、そしてタケダイズム(誠実:公正・正直・不屈)を日々の業務で体現しています。私たちは、237年の研究開発型の製薬企業としての伝統のもと団結し、優れた医薬品の創出を通じて、人々の健康と医療の未来に貢献することをミッションとして掲げています。 

[Goal]

Oligonucleotide therapeutics such as antisense oligonucleotides (ASOs) is a promising drug platform for the treatment of neurological diseases. ASOs expand the set of druggable targets, which small-molecules and mAbs cannot access. However, currently oligonucleotides must be administered directly into the cerebral spinal fluid by invasive intrathecal administration to deliver inside the brain. Systemic administration with a novel DDS (drug delivery system) which could transfer ASO to the brain from blood represents many clinical benefits to patients. Our goal is to discover novel DDS which allow systemic administration of ASO to deliver into the brain.

[Accountabilities]

  • This position is accountable for hypothesis generation, research planning and execution of cutting edge DDS research of ASO delivery by effectively communicating with research partners. In addition, search and evaluation of external technologies are also included in the role.
  • The research covers mechanism of action study via various cells including iPSC, immunohistochemical staining, protein binding analysis, and others.
  • This position is also accountable for reporting and writing research progress timely to one's supervisor.

[Requirements]

Required:

  • Good verbal and written communication skills in Japanese and/or English to work productively as a research team
  • Proactive mindset to effectively drive collaborative researches forward with internal and external partners
  • PhD or equivalent in cell biology, drug delivery, pharmacokinetics or related field
  • Research experience in the field of blood-brain barrier or oligonucleotide DDS

Preferred:

  • Knowledge and expertise of drug discovery in the field of central nervous system diseases, pharmacokinetics, or safety.
  • Research experience of immunohistochemical staining, genetic analysis, proteomics
  • Experience of collaborative research with external partner.

[Employment Type]

Fixed term

[Employee Benefits]

  • Allowances: Commutation, Housing, Overtime Work etc.
  • Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/Yamaguchi) 8:00-16:45, Research Site (Kanagawa) 9:00-17:45
  • Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)
  • Paid Leaves: Annual Paid Leave, Special Paid Leave, Refresh Leave, Maternity Leave, Childcare Leave, Family Nursing Leave, Philanthropy Leave.

待遇

  • 諸手当:通勤交通費、借家補助費、勤務時間外手当など
  • 昇給:原則年1回 
  • 賞与: 原則年2回
  • 勤務時間:本社(大阪市中央区・東京都中央区)9:00~17:30 、工場(山口県光市・大阪市淀川区)8:00~16:45 、研究所(神奈川県藤沢市)9:00~17:45
  • 休日:土曜、日曜、祝日、メーデー、年末年始など(年間123日程度)
  • 働き方関連制度:フレックスタイム制、テレワーク勤務制導入(対象社員)
  • 休暇:年次有給休暇、特別有給休暇、リフレッシュ休暇、産前産後休暇、育児休暇、
  • 子の看護休暇、介護休暇、フィランソロピー休職制度

Locations

Fujisawa, Japan

Worker Type

Employee

Worker Sub-Type

Fixed Term (Fixed Term)

Time Type

Full time

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