Research Scientist II / Sr. Scientist

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Research Scientist II / Sr. Scientist

Cambridge, Massachusetts

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  • Job Type: Full Time
  • Job Level: Senior
  • Travel: Minimal, if any

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Success Profile

What makes a successful team member within Research at Takeda?

  • Inquisitive
  • Organized
  • Agile
  • Innovative
  • collaborative
  • Responsible
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    Design and carry out experiments
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    Manage multiple projects
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    Document data
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    Mentor other scientists

Where You Fit In

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally – and make a difference to patients, people and the planet.

Research Scientist II / Sr. Scientist

Job ID R0053697 Date posted Nov. 23, 2021 Location Cambridge, Massachusetts

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Job Description

Position Overview:

We are looking for an experienced Scientist II/Sr. Scientist with expertise in liver diseases, viral/non-viral gene therapy and gene editing for rare diseases. You will be part of a Pathway Sciences team in the Rare Disease Drug Discovery Unit focused on developing novel genetic solutions for rare liver indications.

Primary Responsibilities:

  • Draft and build research plans for generating preclinical data package to support Go/No-go decisions.
  • Develop and troubleshoot disease/ target specific cell-based, biochemical and functional assays supporting proof of mechanism with novel approaches in liver gene therapies.
  • Collaborate across Takeda's research infrastructure and also work with external KOLs or research partners to accelerate programs to essential milestones.
  • Provide technical guidance to other members of the team and DDU.
  • You will engaged in hypothesis generation, establishing early proof-of-concept and managing parallel workstreams across partner lines within the project team.

Requirements:

  • PhD in Hepatology, Biology, Genetics/Genomics, or related fields with 3+ years of experience in liver diseases, gene therapy/gene editing and viral/non-viral delivery vectors or MS with 9+ years or BS with 11+ years of relevant experience.
  • Experience with in-vitro and in-vivo liver models using Primary human hepatocytes, hepatic cell lines, humanized liver models, gene delivery to the liver.
  • Experience with novel gene delivery and gene-editing modalities.
  • Experience working within teams and performing studies working with CROs or partners.
  • Enthusiasm to work on novel technologies.
  • Experience providing simultaneous contributions to multiple programs.
  • You will have in-depth understanding of liver biology, hepatic cell models and several aspects of viral/non-viral delivery, functional and phenotypic assay development and completing studies in disease relevant models to support preclinical data package.

This job posting excludes CO applicants.

Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.

Employee may also be eligible for Short-term and Long-term incentive benefits. Employees are eligible to participate in Medical, Dental. Vision, Life Insurance, 401(k), Charitable Contribution Match, Company Holidays, Personal & Vacation Days, Student Loan Repayment Program and Paid Volunteer Time Off. If candidate is not eligible for any benefits or other comp., those can be excluded.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

USA - MA - Cambridge - Binney St

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Our Pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

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What We Believe In

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

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Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.

  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.

  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.

  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 11 companies to receive Top Global Employer® status for 2022.

  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.

  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

I feel especially lucky to be able to work with colleagues across the industry to meet a unified goal. Takeda is paving the way for how research will be conducted in the future.

Daniel Scheibe Senior Manager Operations, Systems Engineering, Drug Discovery Sciences

We are operating at the cutting edge of science. It’s exciting to be part of these pioneering efforts – to explore unique targets that may lead to transformative medicines.

Sami Bahmanyar Director Computational Chemistry, Drug Discovery Sciences

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We take action by focusing on our four priorities

  • Create an exceptional people experience
  • Responsibly translate science into highly innovative, life-changing medicines and vaccines
  • Protect our planet
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About our location

Cambridge, Massachusetts

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