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As one of the world’s leading biopharmaceutical companies, Takeda is committed to bringing Better Health and a Brighter future to people worldwide. We aspire to bring our leadership in translating science into life-changing medicines to the next level, in our core focus areas; oncology, gastroenterology, neuroscience, rare diseases, plasma-derived therapies, and vaccines. The Greater Boston Area is headquarters to many of our Global and US business units.
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Research & Development
By focusing R&D efforts on four therapeutic areas and other targeted investments, our aim is to thrive at the cutting edge of innovation that solves unmet medical needs, through internal R&D and in collaboration with cross-industry partners. We have the scale and expertise to be a leading global, Values-based, R&D-driven biopharmaceutical company with dynamic, focused R&D efforts.
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Recognized for our culture and way of working, we’re one of only 13 companies to receive Top Global Employer® status for 2020.
Research InvestigatorApply Now
Responsible for cell line development (CLD) activities including transfection, stable selection, cell culture maintenance, clone selection, and genetic engineering and characterization of mammalian cell lines for clinical and commercial production.
This position will play an important role in a group developing stable CHO cell lines for the production of therapeutic antibodies and proteins. This may include performing laboratory experiments using a variety of CLD and cell culture technologies including single cell cloning, cell imaging, clone screening, liquid handling automation and Octet/ELISA-based recombinant protein quantification.
This position also independently optimizes current process and develops new methods and technologies to improve platforms and processes.
- Employs available methods and test new methods for cell line development and independently generates CHO cell lines of high productivity and quality
- Performs phenotypic and genotypic characterizations of the cell lines
- Works with departmental and/or cross functional peers to execute on assignments under limited supervision.
- Interprets data independently, identifies technical issues and implements solutions under limited supervision
- Contributes to the design of new applications and operations in consultation with supervisor; evaluates new technologies and participates in new platform development
- Documents experimental procedures with electronic notebook and authors CLD reports for regulatory filings
- Presents study results in internal meetings, participates in project meetings/decisions
- The candidate will need strong skills with MS Word, Excel and PowerPoint to organize and document experimental procedures with electronic notebook and to prepare CLD reports as supporting documents for IND and BLA filing
EDUCATION, EXPERIENCE AND SKILLS:
- Bachelor’s degree in biochemistry, biology, biotechnology, or related pharmaceutical science; 7+ years of biotechnology/biopharmaceutical industry experience in cell line development
- Master’s degree in biochemistry, biology, biotechnology, or related pharmaceutical science; 4+ year of biotechnology/biopharmaceutical industry experience in cell line development
- Previous experience in cell culture and aseptic techniques is required
- Previous experience in CLD technologies including culture of mammalian cells, single-cell cloning, clonality assessment, and clone screening is highly desirable
- Analytical and Problem-Solving Skills - Ability to troubleshoot and resolve critical and routine issues using appropriate information
- Teamwork - Ability to work within department groups/team
- Organization – Ability to manage work load efficiently and in timely manner especially when projects are at a critical stage
- Technical - Proficiency in use of applicable lab equipment and operations; experience in maintaining written records of work in the form of laboratory notebooks (paper or electronic)
- Communication - Ability to report data, present findings to management
- Computer experience in common Microsoft applications (Word, Excel, PowerPoint) is required
Job ID R0023669