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Research Investigator

Cambridge, Massachusetts


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Research Investigator

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Job ID R0023669 Date posted 10/07/2020 Location Cambridge, Massachusetts

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Job Description


Responsible for cell line development (CLD) activities including transfection, stable selection, cell culture maintenance, clone selection, and genetic engineering and characterization of mammalian cell lines for clinical and commercial production.

This position will play an important role in a group developing stable CHO cell lines for the production of therapeutic antibodies and proteins.  This may include performing laboratory experiments using a variety of CLD and cell culture technologies including single cell cloning, cell imaging, clone screening, liquid handling automation and Octet/ELISA-based recombinant protein quantification. 

This position also independently optimizes current process and develops new methods and technologies to improve platforms and processes.


  • Employs available methods and test new methods for cell line development and independently generates CHO cell lines of high productivity and quality
  • Performs phenotypic and genotypic characterizations of the cell lines
  • Works with departmental and/or cross functional peers to execute on assignments under limited supervision.
  • Interprets data independently, identifies technical issues and implements solutions under limited supervision
  • Contributes to the design of new applications and operations in consultation with supervisor; evaluates new technologies and participates in new platform development
  • Documents experimental procedures with electronic notebook and authors CLD reports for regulatory filings
  • Presents study results in internal meetings, participates in project meetings/decisions 
  • The candidate will need strong skills with MS Word, Excel and PowerPoint to organize and document experimental procedures with electronic notebook and to prepare CLD reports as supporting documents for IND and BLA filing



  • Bachelor’s degree in biochemistry, biology, biotechnology, or related pharmaceutical science; 7+ years of biotechnology/biopharmaceutical industry experience in cell line development
  • Master’s degree in biochemistry, biology, biotechnology, or related pharmaceutical science; 4+ year of biotechnology/biopharmaceutical industry experience in cell line development
  • Previous experience in cell culture and aseptic techniques is required
  • Previous experience in CLD technologies including culture of mammalian cells, single-cell cloning, clonality assessment, and clone screening is highly desirable
  • Analytical and Problem-Solving Skills - Ability to troubleshoot and resolve critical and routine issues using appropriate information
  • Teamwork - Ability to work within department groups/team
  • Organization – Ability to manage work load efficiently and in timely manner especially when projects are at a critical stage
  • Technical - Proficiency in use of applicable lab equipment and operations; experience in maintaining written records of work in the form of laboratory notebooks (paper or electronic)
  • Communication - Ability to report data, present findings to management
  • Computer experience in common Microsoft applications (Word, Excel, PowerPoint) is required


Cambridge, MA

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Full time

Job ID R0023669

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