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Research Investigator

Cambridge, Massachusetts

Overview

Takeda fosters a collaborative and stimulating work environment filled with opportunity and the chance to make a difference in people's lives. It is a workplace driven by integrity, one of Takeda’s long-held values that extends to both the patients we serve and our employees who develop and deliver medicines. Across our company, Takeda employees bring together diverse strengths that together create a stronger whole.

As one of the world’s leading biopharmaceutical companies, Takeda is committed to bringing Better Health and a Brighter future to people worldwide. We aspire to bring our leadership in translating science into life-changing medicines to the next level, in our core focus areas; oncology, gastroenterology, neuroscience, rare diseases, plasma-derived therapies, and vaccines. The Greater Boston Area is headquarters to many of our Global and US business units.

We are a passionate team doing important work that impacts patients’ lives. If you are driven to create better health and a brighter future, join us!

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  • Collaborative
  • Strategic
  • Results Driven
  • Team Player
  • Versatile
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Opportunity

  • Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.

  • Since 1781, the values of Takeda-ism (Integrity, Fairness, Honesty, and Perseverance) have guided everything we do—from decision-making to interacting with patients.

  • Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.

  • Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

  • A strong, borderless team, we strive together towards our priorities and inspiring mission.

  • Recognized for our culture and way of working, we’re one of only 13 companies to receive Top Global Employer® status for 2020.

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Research Investigator

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Job ID R0023669 Date posted 10/07/2020 Location Cambridge, Massachusetts

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Job Description

OBJECTIVE: 

Responsible for cell line development (CLD) activities including transfection, stable selection, cell culture maintenance, clone selection, and genetic engineering and characterization of mammalian cell lines for clinical and commercial production.

This position will play an important role in a group developing stable CHO cell lines for the production of therapeutic antibodies and proteins.  This may include performing laboratory experiments using a variety of CLD and cell culture technologies including single cell cloning, cell imaging, clone screening, liquid handling automation and Octet/ELISA-based recombinant protein quantification. 

This position also independently optimizes current process and develops new methods and technologies to improve platforms and processes.

ACCOUNTABILITIES: 

  • Employs available methods and test new methods for cell line development and independently generates CHO cell lines of high productivity and quality
  • Performs phenotypic and genotypic characterizations of the cell lines
  • Works with departmental and/or cross functional peers to execute on assignments under limited supervision.
  • Interprets data independently, identifies technical issues and implements solutions under limited supervision
  • Contributes to the design of new applications and operations in consultation with supervisor; evaluates new technologies and participates in new platform development
  • Documents experimental procedures with electronic notebook and authors CLD reports for regulatory filings
  • Presents study results in internal meetings, participates in project meetings/decisions 
  • The candidate will need strong skills with MS Word, Excel and PowerPoint to organize and document experimental procedures with electronic notebook and to prepare CLD reports as supporting documents for IND and BLA filing

EDUCATION, EXPERIENCE AND SKILLS: 

Required:

  • Bachelor’s degree in biochemistry, biology, biotechnology, or related pharmaceutical science; 7+ years of biotechnology/biopharmaceutical industry experience in cell line development
  • Master’s degree in biochemistry, biology, biotechnology, or related pharmaceutical science; 4+ year of biotechnology/biopharmaceutical industry experience in cell line development
  • Previous experience in cell culture and aseptic techniques is required
  • Previous experience in CLD technologies including culture of mammalian cells, single-cell cloning, clonality assessment, and clone screening is highly desirable
  • Analytical and Problem-Solving Skills - Ability to troubleshoot and resolve critical and routine issues using appropriate information
  • Teamwork - Ability to work within department groups/team
  • Organization – Ability to manage work load efficiently and in timely manner especially when projects are at a critical stage
  • Technical - Proficiency in use of applicable lab equipment and operations; experience in maintaining written records of work in the form of laboratory notebooks (paper or electronic)
  • Communication - Ability to report data, present findings to management
  • Computer experience in common Microsoft applications (Word, Excel, PowerPoint) is required

Locations

Cambridge, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job ID R0023669

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