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Head of Gene Therapy Technologies

Cambridge, Massachusetts


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Head of Gene Therapy Technologies

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Job ID SR0044209 Date posted 09/30/2020 Location Cambridge, Massachusetts


Are you looking for a patient-focused company that enables transformative technologies to address patients’ needs while inspiring you and support your career? Takeda is a world-class organization where we combine our expertise in disease biology, modality technologies and drug development experience to develop gene therapies in a holistic approach. We are seeking a highly motivated leader with substantial experience in vector design and gene therapy drug development experience to join Takeda to advance our gene therapy research effort. Be empowered and join us as a Head of Analytical & Bioassays in the Global Gene Therapy Research Team.


As one of the leaders of the Global Gene Therapy (GGT) Research Team, the Head of Gene Therapy Technologies will be responsible and accountable for leading a team of technology leads that contributes to discovery research and technology gene therapy (GT) projects. The incumbent will lead the team to continue to establish collaborations across multiple line functions to progress GT projects in a highly matrixed manner.


  • Provide leadership to a team to conduct new technologies and external collaboration projects. Responsible and accountable for appropriate decision making, data interpretations of the results of studies conducted by self and team members.
  • Represent the Gene Therapy Technology team as the GGT LT member. Ensure cross team collaboration within GGT to obtain required resources to enable efficient progression of GT projects.
  • Enable team members to cross collaborate within the GGT team, multiple Discovery Disease Units (DDUs), global research platforms and other departments.
  • Constantly oversees project progression, experimental prioritization and communicate effectively to GGT LT in a timely manner.
  • Ability to balance multiple projects under a demanding timeline while providing guidance to a team of scientists.
  • Evaluation of business development opportunities to support the GGT and R&D portfolio and strategy across multiple therapeutic areas by conducting due diligence evaluations and propose and negotiation of research plans.
  • Serves as the subject matter expert to critically assess external Gene therapy therapeutic assets and enabling technologies and provide comprehensive evaluation from technical, business and strategic perspectives.
  • Provides strategic input on how to combine multiple sources of external collaboration technologies to advance capabilities of GGT in contributing to generating competitive and differentiating gene therapy products.
  • Responsible for input into decisions related to external studies, assessing the technical feasibility, contribute to experimental designs that would yield meaningful outcome that would allow the making of data-driven go/no-go recommendation.
  • Collaborate closely with other GGT functions and identify resources required to enable and/or enhance the execution of the external collaboration projects.
  • Generation of budget and timeline proposals in conjunction with internal and/or external teams.
  • Knowledgeable in competitive landscape of the same and similar targets in our portfolio.
  • Accountable for the development of organizational culture and capabilities. Ability to balance multiple projects under a demanding timeline while providing guidance to a team of scientists.
  • Responsible for management of resourcing and budget planning for his/her area of focus.
  • Demonstrate good organizational and communication skills. Expected to be accountable for effectiveness and timelines of completion of project goals.
  • Follow compliance of documentation in electronic lab notebook and author scientific reports that supports internal documentation and regulatory submissions.


Technical/Functional (Line) Expertise

  • Outstanding expertise and depth of knowledge within a scientific area
  • Keeps up with the up-to-date scientific advancement (e.g. competitive landscape, new technology, new research portfolio, and new partnership)


  • Scientific leadership role, setting high standards for effectiveness of execution, and rigor of thought
  • Has significant managerial responsibility


  • Initiates and leads external interactions and collaborations
  • Frequent contact with internal and external personnel at various management levels


  • Determines methods on new assignments; makes strategic recommendations on projects


  • PHD degree in a scientific discipline with 12+ years of research experience, including 7 years of industry experience required. Prior managerial experience is also required.
  • Contribute to and innovate in the quickly evolving field of gene therapy.
  • Previous experience successfully leading an external collaboration (academic and/or industry) involving design of study plan, oversees execution and frequent evaluation of results to provide decision recommendations. Demonstration of successful go/no-go decision in asset and technologies in-licensing would be a plus.
  • Understanding of compliance and work with external collaborators with a mindset of documentation requirement needed for further utilization of data in future regulatory filing. Prior experience in leading and/or involvement in successful technology and data transfer from external partner to internalize project is a plus.
  • Diplomacy and positive influencing abilities with excellent communication skills are essential for this role.
  • Attend relevant scientific conferences and stay on top of literature publication to stay current in relevant research.
  • Ability to conduct business travel (15-20%), including overnight trips. Some international travel may be required.
  • As a global organization, availability to participate in early or late meetings/teleconferences.

Notice to Employment / Recruitment Agents:

Employment / Recruitment agents may only submit candidates for vacancies only if they have written authorization to do so from Shire, a wholly-owned subsidiary of Takeda’s Talent Acquisition department. Any agency candidate submission may only be submitted to positions opened to the agency through the specific Agency Portal. Shire, a wholly-owned subsidiary of Takeda will only pay a fee for candidates submitted or presented where there is a fully executed contract in place between the Employment / Recruitment agents and Shire, a wholly-owned subsidiary of Takeda and only if the candidate is submitted via the Agency Portal. Candidates submitted or presented by Employment / Recruitment Agents without a fully executed contract or submitted through this site shall not be deemed to form part of any Engagement for which the Agency may claim remuneration.

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Shire, a wholly-owned subsidiary of Takeda, is an Equal Opportunity Employer committed to a diverse workforce. Shire, a wholly-owned subsidiary of Takeda, will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

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Shire, a wholly-owned subsidiary of Takeda, is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Job ID SR0044209

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