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Associate Director, Investigative Toxicology

Cambridge, Massachusetts

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Takeda fosters a collaborative and stimulating work environment filled with opportunity and the chance to make a difference in people's lives. It is a workplace driven by integrity, one of Takeda’s long-held values that extends to both the patients we serve and our employees who develop and deliver medicines. Across our company, Takeda employees bring together diverse strengths that together create a stronger whole.

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Associate Director, Investigative Toxicology

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Job ID R0023907 Date posted 10/16/2020 Location Cambridge, Massachusetts

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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Associate Director, Investigative Toxicology in our Cambridge, Massachusetts office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As an Associate Director, Investigative Toxicology, you will be empowered to provide leadership and global functional expertise for projects in the Takeda portfolio.

OBJECTIVE:

  • Lead Investigative Toxicology | Lead a team of investigative toxicologists detecting and de-risking toxicities in a fast-moving portfolio focused on new modalities. 
  • Help us make safer drugs | The next generation of life changing medicines include gene therapies, oligonucleotides, cell therapies and other new modalities - all honed to treat previously untreatable diseases.   Help us shape this next generation of life-saving medicines by improving the design of next-generation therapeutics based on proactive detection & de-risking of dose limiting toxicities related to liver. 
  • Deliver decision-making data | Lead a team of talented scientists delivering state-of-the-art in vitro assays to detect & de-risk toxicity for medicines in discovery & development.  Help shape the evolution of cell & gene therapies to deliver safer & more effective medicines for patients with rare diseases.

ACCOUNTABILITIES:

  • Lead toxicological investigations to detect & de-risk toxicities in drug discovery and development using in vitro and in vivo data. 
  • Use cutting edge molecular and cellular technologies to help make the next generation of gene and cell therapies.  From single cell RNAseq to organ on a chip technologies – we are looking for scientists with an incredibly deep toolset to solve problems facing a vast field of new modalities.    
  • Probe molecular and cellular mechanisms of toxicity to determine drivers of liver, lung and cardiovascular toxicities and guide drug projects to make safer medicines using your experience, in-house, and literature data. 
  • Drive the development of safer gene and cell therapies using in vitro and in vivo data from a matrixed project team.    

EDUCATION, BEHAVIOURAL COMPENTENCIES AND SKILLS:

  • PhD in biology, pharmacology, toxicology or a related discipline with at least 10 years of pharmaceutical toxicology experience.
  • 5y of Industry experience.
  • 5y of management experience.
  • Experience with conventional and advanced cell culture approaches with cell lines, primary cells, and iPSC cells.
  • Experience working with new modalities - including gene, cell, nanoparticle and/or microbial therapeutics is highly desirable. 
  • Experience working in a matrixed team environment at a pharmaceutical company and/or CRO is essential. 
  • Broad scientific knowledge including pharmacology, toxicology, pathology, physiology and biochemistry.
  • Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker development and application, and for de-risking drug candidates. 
  • Experience with organ systems in addition to liver such as cardiovascular, GI, and immune systems is highly desired
  • Strong interpersonal and organizational skills, especially as a manager, a plus. 
  • Excellent oral and written communication skills

WHAT TAKEDA CAN OFFER YOU:

  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

Learn more at takedajobs.com.

Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit http://www.takeda.us/careers/EEO_Policy_Statement.aspx

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Locations

Cambridge, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job ID R0023907

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