Scientist/Sr. Scientist, Bioinformatics

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Scientist/Sr. Scientist, Bioinformatics

Cambridge, Massachusetts

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  • Job Type: Full Time
  • Job Level: Senior
  • Travel: Minimal, if any

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Success Profile

What makes a successful team member within Research at Takeda?

  • Inquisitive
  • Organized
  • Agile
  • Innovative
  • collaborative
  • Responsible
  • lab icon
    Design and carry out experiments
  • lab icon
    Manage multiple projects
  • lab icon
    Document data
  • lab icon
    Mentor other scientists

Where You Fit In

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally – and make a difference to patients, people and the planet.

Scientist/Sr. Scientist, Bioinformatics

Job ID R0053566 Date posted Nov. 30, 2021 Location Cambridge, Massachusetts

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

OBJECTIVES/PURPOSE:

  • Integrate and analyze pre-clinical and clinical, internal and public domain datasets, to generate and evaluate actionable hypotheses for drug combination, new disease indications, and mechanism of action purposes.

  • Apply state-of-the-art machine learning and deep learning methods for clinical biomarker identification and validation, on various types of data including molecular profiling data, imaging, unstructured text data, EHR data, RWE, and more.

  • Support translational and clinical bioinformatics needs for key oncology cell therapy clinical projects, including high-throughput data QC, processing, analysis and integration.

  • Drive collaborations with internal groups, external partners, including CROs and academia for data analysis and machine learning.

ACCOUNTABILITIES:

  • Independently represent bioinformatics function on global project teams in support of oncology cell therapy clinical science and translational research projects.

  • Play a leadership role in the development and review of the study synopsis, protocol, biomarker analysis plan, clinical study report, ensuring accurate and valid deliverables.

  • Perform end-to-end data analyses, from hypotheses formulation, experimental design, writing analysis plans, data cleaning, executing analysis, and preparing reports and documentation.

  • Interact closely with biologists and clinicians to conduct analyses, data integration and data interpretation.

  • Identify, build, evaluate and use bioinformatic pipelines to process and QC omics data types including genomics, transcriptomics, single cell sequencing, spatial genomics, proteomics, metabolomics, immunophenotyping and other omics technologies.

  • Interpret preclinical and clinical datasets using appropriate computational and statistical methods.

  • Create visualizations, interpret high dimensional data and explain results to cross-functional teams.

  • Plan and coordinate computational biology activities internally and in partnership with external CROs and academic partners, including complex projects requiring collaboration with multiple members of the team and organizations.

  • Prepare and present comprehensive scientific reports to a full range of internal and external audiences.

  • Work collaboratively with data scientists and data engineering groups at DSI to enhance our computational infrastructure, user interface, query and visualization capabilities.

  • Writes study reports and presents data effectively in all settings and with participants of all levels of the organization.

  • Receives high level instructions on all work, determines methods for new assignments, works closely with manager, mentor junior staff

  • Determines methods for new assignments; perform literature search as needed to propose innovative solutions

  • Independently manages own workload

  • Conducts scientific presentations to internal audiences

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • PhD degree in a scientific discipline, (with 5+ years experience for Sr. Scientist), or

  • MS with 5+ (10+ for Sr. Scientist) years experience, or

  • BS with 7+ (12+ for Sr. Scientist) years experience

  • Passion about science and technologies

  • Strong background with high dimensional data analysis derived from Next Generation Sequencing, including some of the following: RNASeq, DNASeq, epigenomics, single cell sequencing, and immune profiling data.

  • Strong scientific understanding of molecular biology and genomics, as well as disease biology such as cancer and immunology.

  • Knowledge of and experience with machine learning, deep learning, statistical inference and bioinformatic techniques.

  • Hands-on experience developing and implementing bioinformatic pipelines for data analysis of RNASeq, DNASeq, single cell datasets, and immunophenotyping data.

  • Solid knowledge of Unix/Linux, command line interfaces, and fluency in some common scripting and/or programming language (e.g., R, Python, Perl, Java, C / C++).

  • Familiarity with parallel computing, relational databases (e.g., SQL) and cloud computing or distributed computing (i.e. AWS, HPC).

  • Theoretical knowledge of bioinformatics, computational biology; keeps current with emerging trends in bioinformatics and computational biology.

  • Familiarity with popular public domain data sources and API.

  • Experience in designing and conducting computational biology activities to meet program objectives; able to provide input on timelines and resource needs as indicated.

  • Able to evaluate/develop computational methods based on project needs.

  • Excellent problem solving, communication, presentation, and interpersonal skills.

  • Independent, self-starting and supportive of team-based research and able to work effectively in a matrix organization.

  • Ability to work in a team and influence team to make data driven decisions

  • Ability to search literature and come up with innovative solution to difficult problems

  • Background in cell/gene therapy, oncology or immunology is a plus

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

WHAT TAKEDA CAN OFFER YOU:

  • 401(k) with company match and Annual Retirement Contribution Plan

  • Tuition reimbursement Company match of charitable contributions

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs

  • Empowering Our People to Shine

  • Discover more at takedajobs.com

No Phone Calls or Recruiters Please.

Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.

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This job posting excludes CO applicants.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Cambridge, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Our Pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

Learn More

What We Believe In

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

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  • Perseverance icon Perseverance

Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.

  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.

  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.

  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 11 companies to receive Top Global Employer® status for 2022.

  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.

  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

I feel especially lucky to be able to work with colleagues across the industry to meet a unified goal. Takeda is paving the way for how research will be conducted in the future.

Daniel Scheibe Senior Manager Operations, Systems Engineering, Drug Discovery Sciences

We are operating at the cutting edge of science. It’s exciting to be part of these pioneering efforts – to explore unique targets that may lead to transformative medicines.

Sami Bahmanyar Director Computational Chemistry, Drug Discovery Sciences

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We take action by focusing on our four priorities

  • Create an exceptional people experience
  • Responsibly translate science into highly innovative, life-changing medicines and vaccines
  • Protect our planet
  • Unleash the power of data and digital

About our location

Cambridge, Massachusetts

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