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Scientist, Oncology Cell Therapy Innovation - Platform Design & Genetic Engineering

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Job ID R0046938 Date posted Sep. 08, 2021 Location Boston, Massachusetts

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist, Oncology Cell Therapy Innovation - Platform Design & Genetic Engineering in our Cambridge, MA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

As a Scientist/Senior Scientist, working on the Oncology Cell Therapy Innovation team, you will be empowered to build a world class cell therapy team to drive cell platform innovation and discovery.

POSITION OBJECTIVES:

This Scientist/Senior Scientist role will be leading the development of pipeline project and platform innovation and play an key role in designing the platform and/or analytical methods for developing cellular therapy products, including primary gdT, primary NK cell, iPSC derived-T cell or NK cell product. Independently plans and executes platform and assay development, characterization and qualification studies to deliver the cellular therapy platform and target selection. Prepares study protocols, reports, technology transfer documentation, regulatory documents, and database integration. Collaborate with multiple functional and matrix project team and presents study results at team or department meetings, to external partners or at conferences. 

POSITION ACCOUNTABILITIES:

  • Understands project timelines and deliverables and plans/coordinates project work accordingly with departmental, functional and external stakeholders.

  • Provides technical leadership to project teams within area of expertise and commits resources to execute specific project tasks.

  • Contributes significantly and independently to project work which may include multiple projects within functional area.

  • Support NK, gdT and iPSC-derived cellular therapy product development.

  • Reviews, interprets and communicates data cross-functionally within project teams.

  • Plans and implements resolutions to technical problems/issues.

  • Supports local and global initiatives which may include leading initiatives or work streams.

  • Serves as a technical resource for junior staff and leverages expertise in laboratory technology as a functional resource/trainer.

  • Independently designs and executes experiments, and reports results.

  • Assists with development of project strategy and communicates complex data/decisions within department and cross functionally as necessary.

  • Builds and maintains relationships with key vendors and assists with technical aspects of vendor negotiations.

  • Responsible for integrating scientific/technical efforts around cross-functional issues.

EDUCATION, EXPERIENCE, BEHAVIOURAL COMPETENCIES AND SKILLS:  

Education and Experience:

Required:

  • Ph.D. with experiences in cellular and molecular biology, immunology, stem cell biology, or biomedical engineering or related pharmaceutical science; 2-5+ years relevant academic/industry experience.

  • Previous experience with the use of contract facilities.

  • Experience in working in a multi-disciplinary team environment.

  • Demonstrated mastery of subject or area related to field.

Knowledge and Skills:

  • Analytical and Problem-Solving Skills-Able to troubleshoot critical issues or problems, and determine causes and possible solutions.

  • Teamwork-Ability to work well in highly cross functional team environment and across global line functions.

  • Communication Skills-Able to expresses one’s self clearly and concisely within team; documents issues and/or concerns concisely with colleagues; adjusts communication style as appropriate for the audience; timely and effectively communicates issues to supervisor; technical writing skills to support authorship of internal technical documents.

  • Organization-Exercises good time management and prioritization skills and is able to successfully manage multiple tasks simultaneously. 

  • Knowledge Sharing-Ability to capture organizational knowledge; improve solutions, processes, and deliverables through use of information; improve information capital by contributing experience, theories, deliverables, and models for others to use.

  • Resource Management-Ability to manage one’s time within individual, departmental, and corporate goals and timelines; management of internal and external resources.

  • External Involvement-Demonstrated involvement in professional community evidenced by presentation of scientific posters or lectures at professional conferences or events.

  • Technical-Subject matter expertise and knowledge of applicable lab equipment and operations.

LINE FUNCTION SPECIFIC QUALIFICATIONS:

  • Experience in developing cell therapy or biological products, or experience in developing and executing cellular characterization assays, including multi-parameter flow cytometry-based, and multiplexed luminescent readouts.

  • Background in immunology, with an understanding of T and NK cell biology, and experience working with gdT or NK cell is strongly preferred.

  • Experience with primary cell culture, including nutrient and cytokine requirements, and understanding phenotype and functional changes is desired.

  • Understanding of viral transduction principles and processes in primary T and NK cell is strongly preferred.

  • In-depth experience in principles and practices of cell with molecular biology techniques for editing and engineering of T and NK cell is a plus.

  • Experience with stem cell biology (e.g., induced pluripotent stem cells), including cell culture, cell transduction, development and execution of functional in vitro and preclinical methods relevant for various types of immune cell differentiation is a plus.

  • Understanding and experience of using the tools of Design of Experiment (DOE) and Quality by Design (QBD) in process & assay design, development, qualification and validation.

  • Previous exposure to GMP manufacturing of cell therapy or biological products, or participation in technical transfer of clinical processes to a CMO, or tech transfer of product release & characterization or clinical assays to a CRO, or other third party is a plus.

TRAVEL REQUIREMENTS:

  • May require approximately 5-10% travel.

Updated Takeda U.S. Vaccine Requirement:

Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles.  US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.

This job posting exclude Colorado applicants.

WHAT TAKEDA CAN OFFER YOU:

  • 401(k) with company match and Annual Retirement Contribution Plan

  • Tuition reimbursement

  • Company match of charitable contributions

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs

Empowering Our People to Shine

Discover more at takedajobs.com

No Phone Calls or Recruiters Please.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time
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