Scientist I/Computational Biology

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Scientist I/Computational Biology

Boston, Massachusetts

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  • Job Type: Full Time
  • Job Level: Senior
  • Travel: Minimal, if any

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Success Profile

What makes a successful team member within Research at Takeda?

  • Inquisitive
  • Organized
  • Agile
  • Innovative
  • collaborative
  • Responsible
  • lab icon
    Design and carry out experiments
  • lab icon
    Manage multiple projects
  • lab icon
    Document data
  • lab icon
    Mentor other scientists

Where You Fit In

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally – and make a difference to patients, people and the planet.

Scientist I/Computational Biology

Job ID R0041501 Date posted Aug. 19, 2021 Location Boston, Massachusetts

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Job Description

Scientist I/Computational Biology

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?  Join us as a Scientist I/Computational Biology  in our Cambridge, MAor San Diego, CA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission

OBJECTIVES/PURPOSE

  • Analyzing and interpreting high dimensional molecular data for the development of GI Therapeutics
  • Identifying and developing sophisticated computational biology approaches to identify targets and provide translational medicine hypotheses.
  • Generate data insights to drive GI projects, Interface with research teams and support the data analysis and interpretation needs of GI projects
  • Drive collaborations with internal groups, external partners, including CROs and academia for data analysis and machine learning.

ACCOUNTABILITIES

  • Support GI discovery teams to identify novel drug targets and achieve translational medicine objectives using sophisticated computational biology techniques.
  • Interact closely with biologists in the GI DDU to design experimental studies, plan analyses, data integration and data interpretation.
  • Identify, build, and use bioinformatic pipelines to process and QC other omics data types including genomics, transcriptomics, single cell sequencing.
  • Interpret preclinical and clinical datasets using appropriate statistical methods.
  • Create visualizations, interpret high dimensional data and explain results to cross-functional teams.
  • Perform integrative analyses with multi-omics datasets, identifying novel targets and achieving translational medicine goals.
  • Develop machine learning algorithms, including deep neural network algorithms.
  • Independently conduct data analysis tasks within a project scope, exercising judgement to evaluate a variety of statistical factors.
  • Independently keep abreast of current literature computational biology for drug development.
  • Maintain and share code.
  • Plan and coordinate computational biology activities internally and in partnership with external CROs and academic partners, including complex projects requiring multiple members of the team and organization.
  • Prepare and present comprehensive scientific reports to a full range of internal and external audiences.
  • Work collaboratively with data scientists and data engineering groups to enhance our computational infrastructure, user interface, query and visualization capabilities.
  • Process, QC and analyze microbiome datasets (16S and shotgun metagenomics)

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS

  • PhD degree with Post Doc experience, or equivalent.
  • or Master's degree in a scientific discipline, or equivalent with 7 + years experience
  • or Bachelors degree in a scientific discipline, or equivalent with 10+ years experience,
  • Knowledge of and experience with machine learning and bioinformatic techniques.
  • Experience with high dimensional data analysis derived from Next Generation Sequencing, including some of the following: microbiome data, RNASeq, DNASeq, miRNA, copy number, epigenetics, and single cell sequencing
  • Hands-on experience developing and implementing bioinformatic pipelines for Omics datasets.
  • Solid knowledge of Unix/Linux, command line interfaces, and fluency in some common scripting and/or programming language (e.g., R, Python, Perl, Java, C / C++).
  • Familiarity with parallel computing, relational databases (e.g., SQL) and cloud computing or distributed computing (i.e. AWS)
  • Familiarity with Tensorflow/Keras or equivalent deep learning language
  • Theoretical knowledge of bioinformatics, computational biology; Keeps current with emerging trends in bioinformatics and computational biology
  • Familiarity with popular public domain data sources and programmatic interfaces
  • Experience with group and program leadership for assigned programs to help design and direct computational biology activities to meet program objectives; able to provide input on timelines and resource needs as indicated
  • In-depth knowledge of currently assigned computational methods
  • Basic knowledge of science/technology outside specific discipline
  • Strong scientific understanding of molecular biology and genomics
  • Supportive of team-based research and able to work effectively in a matrix organization

VACCINATION REQUIREMENTS:

  • Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles.  US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.

WHAT TAKEDA CAN OFFER YOU:

  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

Discover more at takedajobs.com

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Our Pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

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What We Believe In

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

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Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.

  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.

  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.

  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 11 companies to receive Top Global Employer® status for 2022.

  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.

  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

I feel especially lucky to be able to work with colleagues across the industry to meet a unified goal. Takeda is paving the way for how research will be conducted in the future.

Daniel Scheibe Senior Manager Operations, Systems Engineering, Drug Discovery Sciences

We are operating at the cutting edge of science. It’s exciting to be part of these pioneering efforts – to explore unique targets that may lead to transformative medicines.

Sami Bahmanyar Director Computational Chemistry, Drug Discovery Sciences

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We take action by focusing on our four priorities

  • Create an exceptional people experience
  • Responsibly translate science into highly innovative, life-changing medicines and vaccines
  • Protect our planet
  • Unleash the power of data and digital

About our location

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