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Principal Scientist - Microbiome Sciences

Job ID R0048393 Date posted Sep. 27, 2021 Location Boston, Massachusetts

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Principal Scientist, Microbiome Sciences in our Cambridge, MA offices.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.


Takeda is making significant investments in microbiome drug development for gastrointestinal diseases across therapeutic modalities. We are building a dedicated group of microbiome experts as part of Gastrointestinal Drug Discovery Unit (GI DDU) to advance this growing pipeline. In addition, we are developing multi-year collaborations focused on the next generation of microbiome therapeutics. The selected candidate will expand our microbiome discovery and development capabilities to support our growing microbiome portfolio. This is an opportunity to step into a leadership role progressing preclinical and translational research projects through the discovery pipeline to the clinic.

The GI DDU has a growing interdisciplinary group of individuals focused on gastrointestinal diseases such as inflammatory bowel disease, liver disease, and enteric nervous system/neuroinflammatory diseases. We are looking for a dynamic and driven individual join as an expert in microbiome-based therapeutics. The Research Principal Scientist will have wide visibility within the organization and among our academic and biotech partners.


  • Leads microbiome and inflammation-targeting drug discovery projects for gastroenterological diseases.
  • Establishes project direction integrating science, key technical knowledge, and program
  • Designs and implements preclinical studies in support of clinical and discovery stage assets
  • Plays an active role in the evaluation of potential drug candidates for in-licensing
  • Acts as the scientific lead for Takeda in our academic partnerships focused on microbiome based therapies
  • Builds and implements strategy for emerging areas of microbiome drug discovery including neuroinflammation
  • Develops human-first novel target ID approaches for our discovery pipeline
  • Contributes to the preparation/editing/review of documents for regulatory submission (i.e., study reports, IB’s, IND’s)
  • Establishes rapport and collaborates with microbiome scientific leaders, KOLs, academic partners, CROs, and is seen as an international subject matter expert


Technical/Functional (Line) Expertise

  • Demonstrates well-developed knowledge of other disciplines / departments and how they function together
  • Demonstrates either or both: exceptional project management skills or broad recognition for
    in-depth expertise in a scientific discipline


  • Designs and directs research strategy and activities to meet program objectives; provide
    leadership, timelines and contingency plans             

Decision-making and Autonomy

  • Independently manages workload and expectations
  • Scientifically independent
  • Scientific driver for research strategy that impacts group internally and outside area of function


  • Initiates and leads external interactions and collaborations
  • Frequent contact with internal and external personnel at various management levels
  • Collaborates with other departments, and disciplines, acting as scientific authority within
  • Serves as senior company / project representative at external conferences, or business meetings


  • Determines methods on new assignments; makes strategic recommendations on projects; greater demonstrated independence; may manage junior staff


  • PhD degree in a scientific discipline with 8+ years experience , or
  • MS with 12+ years experience, or
  • BS with 14+ years experience
  • Deep knowledge and experience in the microbiome sciences such as anaerobic microbiology, shotgun metagenomics and/or microbial metabolomics
  • Experience in gut-brain microbiome research
  • Experience with small molecule drug discovery programs strongly preferred
  • Track record of progressing discovery and preclinical programs in an industry setting
  • Experience managing external resources in drug discovery
  • Excellent problem solving, collaborative, communication, presentation, and interpersonal skills
  • Independent, self-starting and experience working effectively in a matrix organization.


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

This job posting excludes CO applicants.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

Worker Type


Worker Sub-Type


Time Type

Full time